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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K5
All Species:
23.94
Human Site:
S133
Identified Species:
37.62
UniProt:
Q13163
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13163
NP_002748.1
448
50112
S133
A
G
P
S
Q
H
S
S
P
A
V
S
D
S
L
Chimpanzee
Pan troglodytes
XP_001174798
467
51808
S133
A
G
P
S
Q
H
S
S
P
A
V
S
D
S
L
Rhesus Macaque
Macaca mulatta
XP_001111645
449
50213
S133
A
G
P
S
Q
H
S
S
P
A
V
S
D
S
L
Dog
Lupus familis
XP_852868
288
32448
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVS7
448
50086
S133
A
G
P
S
Q
H
T
S
P
V
V
S
D
S
L
Rat
Rattus norvegicus
Q62862
448
50179
S133
A
G
P
S
Q
H
T
S
P
V
V
S
D
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516129
399
44778
S88
H
H
S
S
P
T
I
S
E
S
L
P
G
N
S
Chicken
Gallus gallus
NP_001073184
351
39168
S65
A
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Frog
Xenopus laevis
NP_001084729
448
49926
S133
A
G
S
S
S
S
S
S
P
S
V
P
D
N
I
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
V75
I
G
E
K
N
F
V
V
K
A
D
D
L
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
K103
G
N
G
G
V
V
M
K
V
R
H
T
H
T
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
K94
V
N
K
C
V
H
R
K
T
G
V
I
M
A
R
Sea Urchin
Strong. purpuratus
XP_786275
385
43129
A87
C
E
A
R
R
V
M
A
P
P
L
N
I
Y
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
L68
N
Q
L
S
L
A
D
L
E
V
I
K
V
I
G
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
A206
P
N
V
A
P
H
K
A
P
A
I
I
N
T
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
99.5
63.3
N.A.
97.7
98.2
N.A.
82.3
74.1
84.8
30.5
N.A.
35
N.A.
37
49.3
Protein Similarity:
100
93.3
99.5
64.2
N.A.
99.1
99.1
N.A.
86.1
76.1
89.9
47.3
N.A.
54.2
N.A.
53.7
63.1
P-Site Identity:
100
100
100
0
N.A.
86.6
86.6
N.A.
13.3
20
53.3
13.3
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
0
N.A.
93.3
93.3
N.A.
33.3
33.3
73.3
13.3
N.A.
13.3
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.5
42.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
7
7
0
7
0
14
0
34
0
0
0
7
0
% A
% Cys:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
7
0
0
0
7
7
40
0
0
% D
% Glu:
0
7
7
0
0
0
0
0
14
0
0
0
0
7
0
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
47
7
7
0
0
0
0
0
7
0
0
7
0
7
% G
% His:
7
7
0
0
0
47
0
0
0
0
7
0
7
0
7
% H
% Ile:
7
0
0
0
0
0
7
0
0
0
14
14
7
7
7
% I
% Lys:
0
0
7
7
0
0
7
14
7
0
0
14
7
0
0
% K
% Leu:
0
0
7
0
7
7
0
7
0
0
20
0
7
0
34
% L
% Met:
0
0
0
0
0
0
14
0
0
0
0
0
7
0
0
% M
% Asn:
7
20
0
0
7
0
0
0
7
0
0
7
7
14
0
% N
% Pro:
7
0
34
0
14
0
7
0
54
7
0
14
0
0
14
% P
% Gln:
0
7
0
0
34
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
7
7
0
7
0
0
7
0
0
0
0
7
% R
% Ser:
0
0
20
54
14
7
27
54
0
20
0
34
0
40
14
% S
% Thr:
0
0
0
0
0
7
14
0
7
0
0
7
0
14
0
% T
% Val:
7
7
7
0
14
14
7
7
7
20
47
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _